Article Dans Une Revue EFSA Journal Année : 2018

Scientific Opinion about the Guidance of the Chemical Regulation Directorate (UK) on how aged sorption studies for pesticides should be conducted, analysed and used in regulatory assessments

Colin Ockleford
  • Fonction : Auteur
Antonio Hernandez-Jerez
  • Fonction : Auteur
Susanne Hougaard Bennekou
  • Fonction : Auteur
Michael Klein
  • Fonction : Auteur
Thomas Paulien Adriaanse
  • Fonction : Auteur
Theodorus Brock
  • Fonction : Auteur
Sabine Duquesne
  • Fonction : Auteur
Sandro Grilli
  • Fonction : Auteur
Thomas Kuhl
  • Fonction : Auteur
Ryszard Laskowski
  • Fonction : Auteur
Kyriaki Machera
  • Fonction : Auteur
Olavi Pelkonen
  • Fonction : Auteur
Silvia Pieper
  • Fonction : Auteur
Michael Stemmer
  • Fonction : Auteur
Ingvar Sundh
  • Fonction : Auteur
Ivana Teodorovic
  • Fonction : Auteur
Chris Topping
  • Fonction : Auteur
Gerrit Wolterink
  • Fonction : Auteur
Robert Smith
  • Fonction : Auteur
Anne Louise Gimsing
  • Fonction : Auteur
Roy Kasteel
  • Fonction : Auteur
Arnaud Boivin
  • Fonction : Auteur
Ton van der Linden
  • Fonction : Auteur
Jose Oriol Magrans
  • Fonction : Auteur
Mark Egsmose
  • Fonction : Auteur
Aaldrik Tiktak
  • Fonction : Auteur

Résumé

The EFSA Panel on Plant Protection Products and their Residues reviewed the guidance on how aged sorption studies for pesticides should be conducted, analysed and used in regulatory assessment. The inclusion of aged sorption is a higher tier in the groundwater leaching assessment. The Panel based its review on a test with three substances taken from a data set provided by the European Crop Protection Association. Particular points of attention were the quality of the data provided, the proposed fitting procedure of aged sorption experiments and the proposed method for combining results obtained from aged sorption studies and lower‐tier studies on degradation and adsorption. Aged sorption was a relevant process in all cases studied. The test revealed that the guidance could generally be well applied and resulted in robust and plausible results. The Panel considers the guidance suitable for use in the groundwater leaching assessment after the recommendations in this Scientific Opinion have been implemented, with the exception of the use of field data to derive aged sorption parameters. The Panel noted that the draft guidance could only be used by experienced users because there is no software tool that fully supports the work flow in the guidance document. It is therefore recommended that a user‐friendly software tool be developed. Aged sorption lowered the predicted concentration in groundwater. However, because aged sorption experiments may be conducted in different soils than lower‐tier degradation and adsorption experiments, it cannot be guaranteed that the higher tier predicts lower concentrations than the lower tier, while lower tiers should be more conservative than higher tiers. To mitigate this problem, the Panel recommends using all available higher‐ and lower‐tier data in the leaching assessment. The Panel further recommends that aged sorption parameters for metabolites be derived only from metabolite‐dosed studies. The formation fraction can be derived from parent‐dosed degradation studies, provided that the parent and metabolite are fitted with the best‐fit model, which is the double first‐order in parallel model in the case of aged sorption.

Dates et versions

hal-04679191 , version 1 (27-08-2024)

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Colin Ockleford, Antonio Hernandez-Jerez, Susanne Hougaard Bennekou, Michael Klein, Thomas Paulien Adriaanse, et al.. Scientific Opinion about the Guidance of the Chemical Regulation Directorate (UK) on how aged sorption studies for pesticides should be conducted, analysed and used in regulatory assessments. EFSA Journal, 2018, 16 (8), pp.5382. ⟨10.2903/j.efsa.2018.5382⟩. ⟨hal-04679191⟩
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